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In rabbits and cynomolgus monkeys administered semaglutide during organogenesis, early pregnancy losses and structural abnormalities were observed at below the MRHD (rabbit) and 5-fold or greater the MRHD (monkey)

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5 However, caution is warranted on consuming these large doses, as excess intake can cause toxicity

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However, thymosin beta-4s known upregulation in metastatic cancers represents a significant theoretical safety concern