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LPS activates Toll-like receptors (TLRs), particularly TLR4, 72 triggering immune responses and cytokine release

In turn, this phenomenon can triggers a catalytic mechanism for the oxidation of the cellular thiol pool [117,118,119] and of oxidative stress when the homeostatic compensation is overwhelmed by an excessive depletion of the reduced thiol pool, as is the case for cells, such as neurons, that depend on neighboring glial cells for their supply of essential thiol precursors

If you are well hydrated and havent urinated recently, you may pass some fluids more quickly than if the reverse is true (keeping in mind most people are dehydrated and many do not even know it)

In other words, individual variability really matters

Gut-Brain Axis and SERTs : Over 90% of serotonin is produced in the gut, regulated by serotonin transporters (SERTs)

Fine-Chem, Mumbai, India)