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Third, GLP-1 released into the intestinal lumen undergoes rapid degradation by pancreatic proteases and DPP-4, markedly reducing the concentration of active GLP-1 (736) before it can reach GLP1R-expressing target cells ( 10 Conclusion Current evidence indicates that the functional heterogeneity and adaptive potential of -cells in T2D are shaped by both intrinsic molecular programs and extrinsic regulatory cues, among which signals originating from the gut microbiota are particularly prominent