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Generically, we can describe the relationship between body and skin temperatures with the following equation, a solution of the differential heat diffusion equation [1]: () = () + () Where corresponds to the difference, in degrees, between the two temperatures and depends, like skin temperature, on time

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Persistent mild inflammation directly leads to disorders of blood glucose regulation and exacerbates complications such as diabetic nephropathy, cardiovascular diseases, and retinopathy through mechanisms such as impairing the function of pancreatic islet cells, aggravating reduced sensitivity to insulin, and promoting vascular endothelial damage (Figure 3)

Conversely, FXR inhibition or functional antagonism demonstrates therapeutic value where FXR activation is detrimental