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Lifelong endurance training (more than 3 times/week) lower DNA methylation in 714 gene promoters, including those associated with glycolysis, glycogen metabolism, muscular dystrophies, and oxidative stress response in skeletal muscle of the elderly, potentially enhancing the expression of genes involved in muscle metabolism and myogenesis, while the methylation levels of introns, CpG islands and exons appear similar between physically active and inactive groups [132]

Intracellularly, rhodopsin is coupled to a specific G-protein called transducin

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doi: 10.1146/annurev-physiol-021115-105045 122

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Exogenous contributorsincluding bisphenol A, heavy metals, ionizing radiation, and high-fat dietsamplify ROS generation or suppress antioxidant enzyme systems, tipping the redox balance toward cellular injury (3336)