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Total triterpenes of Euphorbium alleviates rheumatoid arthritis via Nrf2/HO-1/GPX4 pathway]

Shanaida M, Lysiuk R, Mykhailenko O, Hudz N, Abdulsalam A, Gontova T, et al

Physiological factors affecting drug toxicity

Although exogenous factors, including infection and inhaled pollutants, could directly oxidize GSH, endogenous disease-specific mechanisms could also prime the process

It supports myelin production, which protects nerve fibers, and helps reduce homocysteine levels that are linked to cognitive decline

Similarly, under oxidative stress, EGCG not only failed to provide protection in hydrogen peroxide-induced model but also worsened mitochondrial membrane potential loss, caspase-3 activation, and DNA fragmentation, suggesting potential pro-apoptotic and mitochondria-damaging effects under such conditions (Sahadevan et al., 2023)