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Age categories followed International Council for Harmonisation (ICH) E11 (R1) guidelines ( This synthesis integrates mechanistic, clinical, and translational evidence without formal systematic review methodology or Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting

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When LPS enters the bloodstream, it strongly activates the immune system, leading to the massive release of pro-inflammatory cytokines and the generation of large amounts of ROS, ultimately resulting in hepatocyte death and acute liver injury ( A novel nano-delivery system named GA/PPC-LNP, with glycyrrhizin as a key component, has been developed