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Description
While this often leads to desired effects such as long-lasting activity, it can also give rise to significant issues later in the drug discovery pipeline, e.g

( a ) Scheme for investigating liver cysteine, cholesterol, total triglycerides (TG), and bile acid levels in response to liver-specific LRRC58 KD in vivo

Hansen and JRW, unpublished data)

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Cardiorenal metabolic syndrome and diabetic cognopathy

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