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Presence of Aqueous Unstirred Diffusion Layer: The pH-shift in the absorption of acidic and basic drugs, as discussed earlier, also accounts for the fact that the bulk of the luminal fluid is not in direct contact with the membrane but a barrier called as aqueous unstirred diffusion layer is interposed between them

The molecular genetics of CAH is of special interest because 75% of mutant alleles arise from gene conversion events in which CYP21 sequences are replaced by corresponding sequences of the CYP21A pseudogene

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