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Environmental stressorsincluding ultraviolet radiation, air pollution, and ozone, as well as physiological factors such as hormonal fluctuations, aging, exposure to pesticides, microbial antigens, and high-sugar diets can elevate ROS levels on the ocular surface, triggering oxidative stress (Honisch et al., 2023)

10.1371/journal.pbio.2005206 101 HomolakJ

Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes

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Moreover, the relationship between DN and other complications, such as cardiovascular autonomic neuropathy, has been established, indicating that these conditions often coexist and may share common pathophysiological mechanisms (de Paula et al., 2024