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NNMT predominantly localizes in adipose tissue and liver (Pissios, 2017)

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Side effects are rare but may include: Mild pain or redness at the injection site Headache Dizziness Upset stomach Reactions are highly uncommon

It is important to use this medicine exactly as prescribed by your doctor or pharmacist

NNMT inhibition improves glucose tolerance, helping your cells use carbohydrates more efficiently to support sustained fat loss

Results announced in October 2025 demonstrated orforglipron's superiority on both HbA1c and weight endpoints, positioning it as a more effective second-line oral agent than existing oral diabetes medications