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doi: 10.1210/endo.137.9.8756584

[33] It does that by increasing the rate at which cells burn fat via a messenger molecule called CAMP and reducing the level of glucose by improving insulin sensitivity

The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

Gao S, Wassler M, Zhang L, Li Y, Wang J, Zhang Y, et al

This is completely normal and does not indicate damage, contamination, or reduced quality

However, the lack of selectivity and low metabolic stability obscured the direct outcome of NNMT inhibition