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Melatonin, on the other hand, is a hormone that's naturally produced in the body

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Glyoxalase I catalyzes the formation of a thiohemiacetal adduct between GSH and MGO and its rearrangement to a thioester

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An initial model was generated by docking de novo-folded ZSWIM8 (AlphaFold3), CUL3 (PDB 5NLB), ELOB/C (PDB 1LM8) and AGO2 (PDB 6NIT) into the composite map

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