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Critically, though dysbiosis worsens chronic inflammation by promoting pathogen dominance and biofilm tenacity, emerging data indicate that recapitulating microbial balance through targeted interventions may curtail AMR

Furthermore, redox-active metals like copper and iron can catalyze the Fenton reaction, generating substantial amounts of ROS, which in turn induces OS and ultimately leads to cell death

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To mimic the reductive half reaction, a glutathione moiety was covalently attached to the active-site cysteine via a disulfide bond in all systems

And aspirin inhibits its own activity by acetylating the K384, K394, and K414 residues of cGAS

doi: 10.3390/cancers13143466