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Coughlin, Q
133 4-HNE readily forms covalent adducts with nucleophilic amino acid residuesparticularly cysteine, histidine, and lysinethrough Michael addition or Schiff base formation, frequently resulting in protein misfolding, unfolding, or aggregation
DOI:10.1093/gerona/glz091 [Google Scholar] Chen J, Wu S, Wu Y, Zhuang P, Zhang Y, Jiao J
It almost never causes water retention or bloating
A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes
