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HO-1, which is involved in heme metabolism, catalyzes the conversion of heme to biliverdin and generates carbon monoxide during this process (Hayashi et al., 1999)

A further question still to be answered is that of the optimum dose when using the oral route [3]

found that SLC25A5 regulates mitochondrial ATP/ADP exchange, maintains mitochondrial functional integrity, and promotes metabolic adaptation and proliferation of CRC cells [56]