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In some embodiments, the otic formulation or composition comprises about 0.1% by weight of the poloxamer

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In clinical trials, first-generation siRNAs (ARC-520 and ARC-521) showed modest reduction in HBsAg (~ 0.5 log IU/mL) in both HBeAg-positive and HBeAg-negative virally suppressed subjects [41]

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