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[44] have identified a number of potential contributors to the elevated placebo response that include the study duration and size, as well as the study design and number of patients at a particular site that should be considered when planning and conducting confirmatory trials in NP

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Likewise FDA-approved agents like Topotecan, a topoisomerase I inhibitor, were found to carry inhibitory effects on HIF-1 translation (156, 158, 160)

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