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Moreover, the 28 days in case of rat is equivalent to 2 years in human life cycle [12]

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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above

As an important group of antioxidative enzymes, the normal levels of GPxs help to control the level of reactive species

To minimize noise inherent to the in vivo measurement environment, a real-time signal-processing algorithm was applied to extract a clear pharmacokinetic profile from the peak-current response [Figure 12C] [131]

Comparison: Direct vs