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In humans, high selenium supplementation (which may increase the expression of GPx1, as well as that of other selenoproteins) was associated with increased risk of type 2 diabetes [103, 104]

[DOI] [PubMed] [Google Scholar] 198.Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, et al

Wang F, Gomez-Sintes R, Boya P

Centrally-stored fat deposits are prone to fatty acid overflow, thereby exerting lipotoxic effects on female reproductive ability [264]

Zinc supplementation, of patients with down syndrome, which often goes along with zinc deficiency, could reduce the number of apoptotic cells [134, 135]