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36 It is noteworthy that most follow-up assessments in studies involving enamel matrix derivatives were conducted over a period of 1 year, whereas the follow-up duration in our trial was 6 months

The NHS gives hydroxocobalamin as an intramuscular injection, but published evidence shows the subcutaneous route is a recognised and similarly effective alternative

This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects

Strength of our study was not needing to use radioactivity or a fluorescence tag to selectively detect modified proteins or peptides (a brief overview of protein detection methods can be found in Table S1)

Long-term safety data from the STEP 5 trial demonstrates that participants who continued therapy for two years experienced most of their side effects during the first 6 months, with markedly fewer events in the second year

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