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CRP can also increase bloodbrain barrier paracellular permeability and enter the brain parenchyma in mice with adult-onset obesity in a dose-dependent manner [144]

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10.4161/epi.4.6.9767 [DOI] [PubMed] [Google Scholar] 29.Zhang F, Jia Z, Gao P, Kong H, Li X, Lu X, et al

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Efficacy and safety of an amino acid jelly containing coenzyme Q10 and l-carnitine in controlling fatigue in breast cancer patients receiving chemotherapy: a multi-institutional, randomized, exploratory trial (JORTC-CAM01) Support

When inflammation arises somewhere in the body, the liver detects the elevated IL-6 and produces CRP as part of the acute-phase response