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However, critical knowledge gaps persist in translating these findings to elderly populations: (1) Existing studies predominantly rely on animal models or young/middle-aged cohorts, with minimal data on long-term efficacy and safety in frail older adults (75 years) exhibiting multimorbidity or polypharmacy

EMS pathophysiology is comparable to tumor biology in that it involves enhanced proliferation, adhesion, and invasion, increased neovascularization in ectopic endometrial lesions, and decreased apoptosis (10)

Iron chelating agents are being studied as potential therapies for ferroptosis diseases, though more in vivo studies are needed to clarify the mechanisms and the effect

Multiple early factors anticipate post-acute COVID-19 sequelae

Thus, given a large range of comparisons of different methods of drug administration in one model, along with the used animal models, the obtained results could be regarded as very reliable