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A 2023 review in Frontiers in Physiology noted that mitochondrial-derived peptides like MOTS-c represent a functionally separate class from growth-hormone-axis compounds such as Tesamorelin underscoring why comparison, rather than substitution, is the right framework for evaluating them

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Early pregnancy, or certain neurological health conditions, such as dementia, MS, or Parkinsons, may also cause it
