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In various studies, evidence of cerebral hypoperfusion, cerebral hypertension, autonomic dysregulation, muscular, metabolic, and mitochondrial dysfunction, inflammatory stimulation, redox imbalance, immune abnormalities, small fiber neuropathy, and endothelial dysfunction have been reported, among other findings (Komaroff and Lipkin, 2021)

The Cul3/Rbx-1 E3 ubiquitin ligase has three functional domains, and Nrf2 has seven domains, also known as Nrf2-ECH homology (Neh), 1 through 7 [137]

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