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The PANTHEON trial, a large double-blind RCT in GOLD defined COPD patients with severe airflow obstruction and a history of 2 COPD exacerbations in the previous year, found that NAC 600 mg BID reduced exacerbation rates in NAC group (497 acute exacerbations in 482 patients, 1.16 AcEx/pt/yr) versus placebo (641 acute exacerbations in 482 patients, 1.49 AcEx/Pt/yr), p 1 log 10 ) compared to untreated controls (67)

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

In COPD, curcumin restores HDAC2 expression, reduces H3/H4 acetylation, and increases H3K9 methylation in chemokine gene promoter regions

Undie AS, Weinstock J, Sarau HM, Friedman E (1994) Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain

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Bovine -casein A1 and A2 variants and human healthan update