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Further research reveals that rhein can alleviate endoplasmic reticulum stress induced by H/R, upregulate GPX4 and SLC7A11 to mitigate lipid peroxidation, reduce renal ferroptosis, and protect against AKI (185)

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doi: 10.1016/j.jff.2018.04.059

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Research examining the association between these mutations and cholinergic system integrity found that both were linked to increased basal forebrain volume in asymptomatic stages