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Importantly, resveratrol has been shown to modulate bone marrow-derived dendritic cells, subsequently affecting the secretion levels of IL-22 and IL-10, thereby influencing the progression of atherosclerosis (131)

Phenolic compounds exhibit a anti-genotoxic activity with many mechanisms such as inhibition of promutagens, induction of detoxification mechanism, blocking of free radicals, scavenging of reactive oxygen species, and neutralization of oxidative stress and inhibition of DNA cleavage 66

No significant genotype-dependent differences were observed (Additional file 1: Fig

doi: 10.1038/sj.sc.3100360

However, some molecules or drugs, such as erastin, sulfasalazine, sorafenib, and RSL3, are able to block glutathione synthesis or devitalize GPX4

Together, the present study demonstrates that BPC 157 can modulate the vasomotor tone of an isolated aorta in a concentration- and nitric oxide-dependent manner