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With regard to the therapeutic aspects of Lp(a), it has been found that the therapeutic efficacy of immune checkpoint inhibitors (ICIs) can be enhanced by strategies that reduce Lp(a) levels (e.g., the use of statins or PCSK9 inhibitors) that enhance the response of tumor-specific cytotoxic T cells

In addition, chronic hyperglycemia in patients can lead to circulatory accumulation of lipid peroxidation products and impaired iron metabolism pathways leading to the presence of multiple free irons in plasma

doi: 10.1093/humrep/14.4.1028 39 GrecoEIacobelliMRienziLUbaldiFFerreroSTesarikJ

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While this sensation is typically temporary, it can last for several weeks or even months in some cases