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10.1016/j.jtemb.2010.04.003 J

Key molecular executioners, particularly caspase-1 and MLKL, orchestrate distinct death programs through specific biochemical mechanisms (397)

Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H (2020) Excessive polyamine generation in keratinocytes promotes self-RNA sensing by dendritic cells in psoriasis

More direct in vivo evidence has come from positron emission tomography (PET) studies using the translocator protein (TSPO) tracer 11 C-(R)-PK11195

Trimethylamine N-oxide (TMAO), an important gut microbe-dependent metabolite, is generated from dietary choline, betaine, and L-carnitine

Applications : Enzyme characterization, catalytic studies, and functional protein assays
