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Additionally, IL-6 was significantly different between EXP and CON at 0 (P , 0.01) and 60 min post-test (P , 0.01), with CON having an elevated IL-6 response

This interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, and reactive astrocytes

Zhou X, Xia X, Li L, Ye YMYZJ, Chen Q, Ke M, Cui Q, He Y, Chen Y-T, Lin S-S, Liu W, Wang J (2025) Evaluation of heavy metals and essential minerals in the hair of children with autism spectrum disorder and their association with symptom severity

[3] Bossak-Ahmad, K., Winiewska, M

Taken together, all these observations suggest that a dermal targeting strategy should be considered for melasma treatment apart from the direct controlling tyrosinase of melanocytes