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The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation

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This 15-amino-acid peptide, derived from a protein found naturally in human gastric juice, has demonstrated remarkable tissue repair capabilities across multiple systems

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

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