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doi: 10.3390/molecules28217346 97 AshmorePLValdezFHarbertsonJFBoultonRBCollinsTS

Mechanisms of Glutathione in Cardiovascular Health Antioxidant Defense Glutathione functions predominantly as an antioxidant , effectively scavenging reactive oxygen species (ROS) and preventing oxidative damage

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One study did demonstrate that the multivitamin used for treatment resulted in improvements in biomarkers of energy metabolism (as well as oxidative stress) suggesting that the effect of the multivitamin may have been at least partially related to improvements in mitochondrial function ( in vitro assessment of compounds that may improve mitochondrial function in individuals with ASD ( Folate metabolism Several lines of evidence point to abnormalities in folate metabolism in ASD

In the VPA mice treated with 20 mg/kg piperine, antioxidant markers and behavioral abnormalities could be rescued in comparison to untreated mice [119]