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2.2 Chronic venous insufficiency Two RDP studies on chronic venous insufficiency have shown another interesting clinical application of Pycnogenol ( An RDP study with 40 patients investigated the effects of 300 mg Pycnogenol supplementation per day for two months on subjects with chronic venous insufficiency (CVI) ( significantly relieved swelling (64%) and heaviness (54%) in the legs of CVI patients compared to placebo (7 and 3%, respectively)

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(2021), most patients see measurable improvements within 36 months of consistent use, with continued improvement up to 12 months

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