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doi: 10.1038/s41429-021-00436-z 78 GottwaldEMDussMBugarskiMHaenniDSchuhCDLandauEMet al

Relevant to this review is the link between NAD + levels and T cell-mediated responses against tumors, an area that has gained increasing attention with the recent development of pharmacological inhibitors targeting CD38s enzymatic activities (42)

However, CD38 + NK cell levels seem to remain stable in patients who respond to treatment, in particular, the CD38 + CD56 +dim and CD16 +bright cytotoxic subset

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