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Nevertheless, challenges associated with BMP-2 include its short half-life, complex production equipment and preparation process, as well as supraphysiological doses, which may lead to side effects such as inflammation, pain, heterotopic ossification, or even osteolysis [403]

These powerful molecules have the ability to speed up tissue repair, reduce inflammation, and boost collagen production, making them a go-to ingredient for improving skin health and healing

oxymetazoline topical (Rhofade) niacinamide topical The drug brimonidine topical (Mirvaso) can also be used but it is known for sometimes leading to rebound redness that can be worse than original symptoms

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Dermatol Ther 2021;34:e14924

doi: 10.1016/j.aller.2015.07.007 160 Dey-MartnezAEsteve-SolAVlez-TiradoNCelisVCostaJColsMet al