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If a CYP3A4 inhibitor is discontinued, consider increasing the oxycodone and acetaminophen tablets dosage until stable drug effects are achieved

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Nature 465, 223226

Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components

However, biotransformation may also produce reactive or more toxic metabolites (for example, conversion of methanol to formaldehyde), so detailed knowledge of metabolic pathways is critical for assessing risk and designing antidotes and drugs