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Powerful antioxidant protection for immune health, thyroid function, and cellular defense

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing

doi: 10.1007/s40521-023-00354-5

10.3390/antiox13101186 195 SunH

Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162