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Description
Excess of Methylmalonic acid, which is a myelin destabilizer, can cause the synthesis of abnormal fatty acids instead of myelin[65]
10.1016/j.toxlet.2011.05.1034 276
In addition to BRCA genes, mutations in other high-penetrance genes such as TP53 (associated with Li-Fraumeni syndrome) and PTEN (linked to Cowden syndrome) have been found to be associated with familial breast cancer, as these genes are heritable, keeping women at potential risk to develop cancer during their lifetime ( PALB2, ATM , and CHEK2 (63)
Therefore, these epigenetic modifiers have been targeted for drug development for several years [171,172,173]
Typical daily range: 250500 mcg once daily (gradual titration over 16 weeks)
It is not recommended for children and pregnant women
