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Although CQDs have demonstrated substantial promise in imaging, sensing and drug delivery, advancement beyond preclinical research remains restricted by the scarcity of comprehensive toxicological data and large-scale validation, and addressing these challenges will require close interdisciplinary collaboration across chemistry, materials science, bioengineering, pharmacology, and clinical medicine to establish reliable synthesis methods, robust testing, and safety frameworks aligned with regulatory guidelines [103, 174]

doi: 10.1371/journal.pone.0113721 168 LuLJiangMZhuCHeJFanS