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Description
In the tumor microenvironment, chronic inflammatory factors (e.g., TNF-, IL-1) or ROS activate NF-B, which binds to the promoter region of the Lon gene to enhance its transcription, forming a NF-B Lon upregulation positive feedback loop

The FASEB Journal, 15(7), 12181220

References Alharbi, Khawla, Nnamdi Ekesi, Amer Hasan, Andi Asnayanti, Jundi Liu, Raj Murugesan, Shelby Ramirez, Samuel Rochell, Michael T

2007;293:G110613

Minimizes the appearance of pores

M., Masters C
