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Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence

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A structured reassessment of the pain mechanisms is often the key step in determining why previous treatments were not effective and what needs to be addressed next

18 CeroveckiT.BojanicI.BrcicL.RadicB.VukojaI.SeiwerthS.et al (2010)

Occasionally higher doses are needed
