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These findings suggest that AS-IV exerts synergistic neuroprotective effects at the multicellular level by simultaneously targeting the JNK apoptotic pathway and the NLRP3 inflammatory pathway ( Another study demonstrated that atractylenolide-I (ATR-I), the primary active component of Atractylodes macrocephala Koidz., exhibits significant neuroprotective effects in PD models

Yadav S, Dwivedi A, Tripathi A, Tripathi AK

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Mohajeri et al., 2015)