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The PCA was conducted using the FactoMineR package (52) in R, with the first five principal components capturing the primary sources of variation in the data

In dermal fibroblasts cultured from aged donors, GHK-Cu treatment (2 M) increases TIMP-1 mRNA expression by approximately 25%, contributing to reduced net collagenolytic activity and preservation of existing matrix structures

identified that, uniquely among dopamine precursors or metabolic components, dopamine itself induces cellular iron accumulation during its metabolism (127)

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however, their therapeutic use is limited by their release kinetics, which results in a sharp increase followed by a rapid decrease in H 2 S levels [399,400]