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While inhibition of xCT suppresses cystine uptake and induces ferroptosis, we identified -glutamylcyclotransferase (GGCT), a key enzyme in glutathione (GSH) degradation, as a metabolic compensation pathway that regenerates cysteine to sustain redox homeostasis

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3-O-ethyl ascorbic acid is a vitamin C derivative with an ethyl group attached at the 3-position that prevents oxidation