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93: 85161 Shields RL, Lai J, Keck R, et al

Studies show it affects over 4,000 human genes, with 70% of changes promoting tissue healing and regeneration (Campbell et al., BioMed Research International, 2012)

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Therefore, it is of great clinical value and social significance to seek therapeutic techniques that promote endogenous neurogenesis, to reduce neonatal neurological dysfunction from HIBD

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In conditional mouse mutants, in which the expression of the Igf1r gene was ablated exclusively in neurons and OPC of the cerebrum, there was a reduced accumulation of OPC, leading to a decreased amount of newly generated oligodendrocytes (Mason et al., 2003)