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Lomaestro BM, Malone M. Glutathione in Health and Disease: Pharmacotherapeutic Issues. Ann Pharmacother. 1995;29: 12631273. doi:10.1177/106002809502901213

To mimic ChaC1 overexpression by inducing endogenous ChaC1 high expression, a complementary ChaC1-induction-based screening was performed and revealed proteasome inhibitors (e.g., bortezomib, ixazomib, delanzomib) as potent inducers of endogenous ChaC1 via ATF4-dependent transcriptional activation

perforans race T3, but its transcription was low in the susceptible line OH 88119 whether or not it was infected by the pathogen

This helps prevent common GI issues in older pets such as inflammatory bowel disease (IBD) which can further slow down nutrient absorption

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