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Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke

Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)

Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007
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Concurrently, GHK-Cu influences MAPK pathways including ERK1/2, p38, and JNK, with effects varying based on cellular context and stimulation conditions
