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While the described modulation of cortical excitability is reversible (88), other studies have successfully demonstrated that the excitability-enhancing effects outlasted the stimulation period by several minutes to hours, possibly as a consequence of long-term synaptic changes occurring in the stimulated area (82, 86)

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G., Pozzi, A., Zent, R

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Additionally, the boost in energy from B12 can lead to better mental clarity and focus

These modifications are standard peptide chemistry strategies that preserve the core pharmacophore while improving pharmacokinetic properties