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Furthermore, the hippocampal metabolomic analysis indicated that sleep deprivation affected the metabolism of fatty acid and oxylipins, upregulated the tryptophan-kynurenine metabolic pathway, and exhibited a significant correlation with anxiety and depressive behaviors

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[custom_html]5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid tryptophan to serotonin

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